If you don’t know what Smoke on the Water is by now then it is apparent you haven’t played Grand Theft Auto V. Smoke on the Water is a dispensary that you can purchase on Vespucci Beach using only Franklin. Grand Theft Auto V references and portrays marijuana in a context that is very similar to real life. And, not only does Rockstar advertise the game with marijuana references as seen here rockstargames.com it has done a great job with adding in game social commentary that mimics what is going on today.

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Source: gamersheroes.com

Owning a dispensary is hard work and the in game missions that randomly occur will make you feel like it is one big headache.